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Department of Pathology and Immunology,
Division of Laboratory
& Genomic Medicine,
4320 Forest Park Parkway
Suite #211
Saint Louis, MO 63108
314-362-8853
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| Welcome to Nagarajan
Lab |
Mission
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The goal of biomedical research is to uncover perturbations in important
pathways that lead to disease states so that therapeutic treatments may be
designed. It is clear that most diseases are caused by a set of alterations at
one or more levels of the genetic program. Only through simultaneous monitoring
of DNA, RNA, and protein can the comprehensive understanding of underlying
processes occurring in multi-factorial diseases may be made. While there is a
great need to integrate data derived from functional genomic experiments (e.g.
expression, mutation, CGH, and proteomics profiling) with that ascertained
clinically from the evaluation and treatment of patients, there are no
software, analytical, or visualization applications which can perform this
task. Thus, the primary, long term goals of the Nagarajan lab are to conduct
clinical and biomedical informatics research, to develop software applications
which will simultaneously co-analyze and co-visualize a wide variety of
functional genomics datasets, gene annotation, and clinicopathological data,
and to utilize these heuristic algorithms in order to identify potential
diagnostic markers and putative therapeutic targets. These software based
multiparametric medical diagnostic tests will be used for molecular
"fingerprinting" of tumors and polyfactorial diseases and will ultimately lead
to rational drug design to combat such illnesses.
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Lab Photo
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